抗bodiesinc/GABA-A-R-Beta2/3/75-363/1个
商品编号：
75-363
市场价：
¥0.00
美元价：
0.00
产品分类：
重组抗体
公司分类：
Recombinant_antibodies
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Immunogen:
Fraction of bovine brain GABA-A receptor affinity purified against immobilized benzodiazepine Ro7-1986/1 (1988 de Blas et al J Neurosci PMID 2828565, 1988 Vitorica et al J Neurosci PMID 2828566). Target initially identified as a GABA-A receptor by:
- rat brain immunocytochemistry staining pattern via light microscopy identical to that seen via ligand autoradiography with 3H-muscimol
- immunoprecipitation of 3H-muscimol-binding activity of the purified receptor complex
- recognition of ~57 kDa protein in immunoblots against crude rat brain membrane fractions
Binding epitope identified to be within amino acids 26-40 (QSVNDPGNMSFVKET, extracellular N-terminus, 1992 Ewert et al Brain Res, PMID 1377081) of human GABA-A-R-Beta3 (also known as Gamma-aminobutyric acid receptor subunit beta- 3, accession number P28472)
Mouse: 100% identity (15/15 amino acids identical)
Rat: 100% identity (15/15 amino acids identical)
86% identity (13/15 amino acids identical, QSVNDPSNMSLVKET) with GABA-A-R-Beta2
66% identity (10/15 amino acids identical, HSTNEPSNMSYVKET) with GABA-A-R-Beta1
Hybridoma kindly donated by Angel de Blas, University of Connecticut.
This NeuroMab antibody is considered "Restricted" and is therefore not available for commercial re-distribution on a for-profit basis.
Fraction of bovine brain GABA-A receptor affinity purified against immobilized benzodiazepine Ro7-1986/1 (1988 de Blas et al J Neurosci PMID 2828565, 1988 Vitorica et al J Neurosci PMID 2828566). Target initially identified as a GABA-A receptor by:
- rat brain immunocytochemistry staining pattern via light microscopy identical to that seen via ligand autoradiography with 3H-muscimol
- immunoprecipitation of 3H-muscimol-binding activity of the purified receptor complex
- recognition of ~57 kDa protein in immunoblots against crude rat brain membrane fractions
Binding epitope identified to be within amino acids 26-40 (QSVNDPGNMSFVKET, extracellular N-terminus, 1992 Ewert et al Brain Res, PMID 1377081) of human GABA-A-R-Beta3 (also known as Gamma-aminobutyric acid receptor subunit beta- 3, accession number P28472)
Mouse: 100% identity (15/15 amino acids identical)
Rat: 100% identity (15/15 amino acids identical)
86% identity (13/15 amino acids identical, QSVNDPSNMSLVKET) with GABA-A-R-Beta2
66% identity (10/15 amino acids identical, HSTNEPSNMSYVKET) with GABA-A-R-Beta1
Hybridoma kindly donated by Angel de Blas, University of Connecticut.
This NeuroMab antibody is considered "Restricted" and is therefore not available for commercial re-distribution on a for-profit basis.
Specifications:
Target |
|
GABA-A-R-Beta2/3 |
|
|
||
Applications |
|
Immunoblot (IB) Immunocytochemistry (ICC) Immuno-gold EM Immunohistochemistry (IHC) Immunoprecipitation (IP) |
|
|
||
Clone |
|
62-3G1 |
|
|
||
IgG Isotype |
|
IgG1 |
|
|
||
Species Reactivity |
|
Bovine (B) Chicken (Chk) Human (H) Mouse (M) Rat (R) |
|
|
||
Validation |
|
Br-IB Br-IHC T |
|
|
||
Type |
|
Purified |
|
|
||
Format |
|
100 ul |
|
|
||
Cross Reactivity |
|
Cross-reacts with GABA-A-R-Beta2 Does not cross-react with GABA-A-RBeta1 |
|
|
||
Expected Banding Pattern |
|
55 kDa |
|
|
||
Commercial Price |
|
450 |
|
|
||
Non-Profit Price |
|
200 |
|
|
||
Distributor Price |
|
Per Contract(QUOTE) |
|
|
||
ABID |
|
RRID:AB_2315838 |
|
|
||
品牌介绍
当抗体公司（Antibodies Incorporated）在1962年开业时，与抗体相关的研究才刚刚开始。创始人Jim Hillman拥有博士学位。从药理学明尼苏达大学，来到加州大学戴维斯分校在免疫化学完整的博士后工作，在工作期间，他学习了加州理工学院（加州理工学院）根据丹·坎贝尔，领域的先驱。吉姆带来了他的妻子，公司的共同创始人卡罗尔（Carol）和两个孩子，以及使用基于抗体的化学疗法寻找治疗癌症的能量和想法。具体地说，吉姆认为，如果他能够识别并分离出可能具有抗原性的肿瘤部位（一个焦点是淋巴肉瘤），则可能有可能进行有效的基于抗体的治疗。吉姆寻找这种治疗方法的梦想推动了他的工作多年。
